The effect of silver-containing sorbent on red blood cells during hemosorption: an <i>in vitro</i> study

The aim of the study was to investigate influence original porous silver–containing sorbent on morphofunctional parameters red blood cells during in vitro hemoperfusion. Material and methods. Donor perfused through glass columns filled with a based aluminum oxide, polydimethylsiloxane silver nanoclusters without silver. effect silver-containing change after perfusion sorbents determined by scanning flow cytometry. Results their discussion. Due uniformity distribution (0.1 %) over granules, structure – specific surface area pore volume practically do not compared Morphological donor hemoperfusion are within norm. functional also normal, although introduction slightly increases number active band 3 (B3) proteins erythrocyte membranes, both comparison cell mass as control There is an increase ultimate extensibility membrane (2.2 times) (1.4 times). Conclusions. A modified does have damaging toxic under conditions. mechanisms affecting indicators require further research.